Research

The official home page of my research lab can be found via the Bioinformatics Division on the WEHI website. The WEHI Bioinformatics Division also maintains its own domain at http://bioinf.wehi.edu.au which provides software tools and other resources and useful information.

Students

Past and present research students

Publications

Software

Limma, StatMod and Tweedie Libraries for R. Functions for microarray data analysis and generalized linear models.
StatMod Library for S-Plus. Functions for statistical modelling including dispersion modelling, frequency estimation, robust estimation and categorical data analysis.
StatBox Toolbox for MATLAB. A general statistical toolbox.

Areas of Interest

I am interested in bioinformatics and statistical modelling and computing. For more insight into the role of statistics in bioinformatics see the WEHI Bioinformatics www site or read the Bioinformatics editorial Bioinformatics needs to adopt statistical thinking by Martin Vingron. The main focus of my current work is the design and analysis of gene expression microarray experiments in genetic research, and the arising problems in functional genomics.

Past Interests

Environmental Modelling: I completed a contract for the Queensland Environmental Protection Agency to develop methods for monitoring changes in pollutant levels in Queensland streams and estuaries.

Categorical Data Modelling: Heather Podlich, Malcolm Faddy and I have been developing methods for modelling under- and over-dispersion in categorical data using extended Poisson process models.

Generalized Linear Models: A long-standing interest has been to develop extensions to generalized linear models for the regression modelling of non-normal response data. Current active interests include dispersion modelling, adjusted likelihood methods, data modelling with power variance functions and nonlinear generalized linear models. A recent application is to modelling insurance claims data.

Prony Estimation: Another long-standing interest has been the use of eigen-analysis methods to estimate transient and periodic signals. From a statistician's perspective this means nonlinear least squares with functions defined by differential equations. This includes fitting sums of exponential functions to data and robust frequency estimation.

Other Activities

I am an Associate Editor for the excellent journals Biometrics and Statistical Modelling. I am on the organizing committee for the MGED10 to be held in Brisbane in 2007.